Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow†

Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes.

Aminocarbonylation of aryl halides is one of the most useful methods in amide synthesis, but nitroarenes have not been used as a nitrogen source in this method even though they are more economical and accessible than anilines. Reported here is the development of nickel catalysis for the first three-component reactions of aryl halides, Co2(CO)8, and nitroarenes under reductive conditions to prod...

Stabilized well-dispersed Pd(0) nanoparticles for aminocarbonylation of aryl halides.

Well-dispersed palladium (0) nanoparticles stabilized with phosphonium based ionic liquid were synthesized conveniently and fully characterized. A catalyst system comprising of the Pd(0) nanoparticles and a base was found to be recyclable and efficient for the aminocarbonylation reaction of aryl iodide in ionic liquid media. In the presence of potassium tert-butyloxide, for the relatively stabl...

Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes† †Electronic supplementary information (ESI) available: Experimental and spectra data. See DOI: 10.1039/c7sc03950f

Carbon monoxide free aminocarbonylation of aryl and alkenyl iodides using DMF as an amide source.

[reaction: see text] Palladium-catalyzed coupling reaction of N,N-dimethylformamide with aryl or alkenyl halides successfully proceeded in the presence of phosphoryl chloride to afford the corresponding tertiary amides in good yields.

Palladium(II) Phosphine-Ylide Complexes as Highly Efficient Homogeneous Pre-catalysts for the Ullmann Homocoupling Reaction of Aryl Halides

A highly efficient Ullmann homocoupling reaction of aryl halides using palladium (II) phosphine-ylide complexes as homogenous pre-catalysts under aerobic conditions has been developed without the need for any chemical co‐reducing agents. The procedure is relatively mild and appears to have broad applicability, being useful for the homocoupling of both electron-deficient and electron-rich aryl h...